Across-Scale Depression Severity Ratings in Transcranial Magnetic Stimulation Treatment

Background: The Hamilton Depression Rating Scale (HAMD-17), Beck Inventory (BDI), and Patient Health Questionnaire (PHQ9) are commonly-used scales to classify Transcranial Magnetic Stimulation (TMS) response remission. In the absence of a standard scale, it is critical know whether classifications vary across scales. Methods: This was retrospective chart review 100 patients with treatment-resistant Major who received 30 or more Deep TMS treatments (standard depression protocol) augmented intermittent Theta Burst Stimulation. Four (minimal, mild, moderate, severe) were created based on published standards. HAMD-17, BDI, PHQ9 compared at baseline endpoint analyzed chi-squared tests. Results: varied significantly among (p < 0.001). More in less severe HAMD-17 than BDI PHQ9. Endpoint minimal (remission) classification rates 61% 40% 28% PHQ9, respectively. were: 3% 22% 11% differed 0.05). Conclusions: Classification differences three substantial statistically significant both timepoints. results comparable Brainsway’s HAMD-21 rates, whereas scores suggested poorer treatment responses. research needed evaluate possible clinician (HAMD) patient (BDI, PHQ9) rating biases one these (or another scale) can be considered standard. Conflicts Interests: None Funding: Disclosures: